heparan sulphate

heparan sulphate
(= glycosaminoglycan)
Constituent of membrane-associated proteoglycans. The heparan sulphate-binding domain of NCAM is proposed to augment NCAM-NCAM interactions, suggesting that cell-cell bonds mediated by NCAM may involve interactions between multiple ligands. The putative heparin-binding site on NCAM is a 28 amino acid peptide shown to bind both heparin and retinal cells, as well as to inhibit retinal cell adhesion to NCAM. This strengthens the argument that this site contributes directly to NCAM-mediated cell-cell adhesion.

Dictionary of molecular biology. 2004.

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  • Heparan sulfate — (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. [cite book | title=Proteoglycans:… …   Wikipedia

  • proteoheparan sulphate — A proteoglycan containing as its glycosaminoglycan heparan sulphate whose constituent N acetyl glucosamine is often sulphated. Hence highly negatively charged. Syndecan is one …   Dictionary of molecular biology

  • HS2ST1 — Heparan sulfate 2 O sulfotransferase 1, also known as HS2ST1, is a human gene.cite web | title = Entrez Gene: HS2ST1 heparan sulfate 2 O sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • syndecan — An integral membrane proteoglycan (250 300 kD) associated largely with epithelial cells. The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular… …   Dictionary of molecular biology

  • SULF1 — Sulfatase 1, also known as SULF1, is a human gene.cite web | title = Entrez Gene: SULF1 sulfatase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=23213| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • Glypican 3 — Glypican 3, also known as GPC3, is a human gene.cite web | title = Entrez Gene: GPC3 glypican 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2719| accessdate = ] cite journal | author = Jakubovic BD,… …   Wikipedia

  • glycosaminoglycans — (= formerly mucopolysaccharides) Polysaccharide side chains of proteoglycans made up of repeating disaccharide units (more than 100) of amino sugars, at least one of which has a negatively charged side group (carboxylate or sulphate). Commonest… …   Dictionary of molecular biology

  • Hepatocyte growth factor — Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on… …   Wikipedia

  • Hunter syndrome — Recessive mucopolysaccharidosis, X linked, in which dermatan and heparan sulphates are not degraded. Because two lysosomal enzymes (heparan sulphate sulphatase and a iduronidase) are involved in the breakdown of these glycosaminoglycans,… …   Dictionary of molecular biology

  • glucosamine — Lackie Amino sugar (2 amino 2 deoxyglucose) ; component of chitin, heparan sulphate, chondroitin sulphate, and many complex polysaccharides. Usually found as b D N acetylglucosamine …   Dictionary of molecular biology

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